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	Provedor de dados BJMBR (5) Autor Ribeiro,M.L. (5) Calafatti,S.A. (2) Carvalho-Salles,A.B. (2) Hackel,C. (2) Marchioretto,M.A.M. (2) Pedrazzoli Jr,J. (2) Santos,A. (2) Bernasconi,G. (1) Bernasconi,G.C.R. (1) Cabral,D.F. (1) Cassiano,N.M. (1) Degger,M.F. (1) Deguer,M. (1) Ecclissato,C. (1) Ecclissato,C.C. (1) Ladeira,M.S.P. (1) Mendonça,S. (1) Mesquita,J.C. (1) Moraes,L.A. (1) Ortiz,R.A.M. (1) Mais... Palavra-chave Helicobacter pylori (2) Polymorphisms (2) Prostate cancer (2) 5'Untranslated region (1) AR (1) CYP17 (1) Chronic gastritis (1) Clarithromycin (1) Cytochrome P450 (1) DNA sequence alterations (1) Gastric cancer (1) Hepatitis C (1) Human androgen receptor gene (1) IL-1RN (1) IL-1β (1) Interleukins (1) Lansoprazole (1) Liver function (1) Metronidazole (1) Peptic ulcer (1) Mais... Tipo do documento Info:eu-repo/semantics/article (5) Ano 2012 (1) 2007 (1) 2005 (1) 2004 (1) 2002 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Allelic frequencies of six polymorphic markers for risk of prostate cancer BJMBR Ribeiro,M.L.; Santos,A.; Carvalho-Salles,A.B.; Hackel,C.. The aim of the present study was to evaluate the distribution of polymorphisms for the androgen receptor (AR) (CAG, StuI, GGN), SRD5A2 (Ala49Thr, Val89Leu) and CYP17 (MspA1) genes that are considered to be relevant for risk of prostate cancer. We studied 200 individuals from two cities in the State of São Paulo, by PCR, PCR-RFLP and ASOH techniques. The allelic frequencies of the autosomal markers and the StuI polymorphism of the AR gene were very similar to those described in most North American and European populations. In relation to the CAG and GGN number of repeats, the study subjects had smaller repeat lengths (mean of 20.65 and 22.38, respectively) than those described in North American, European and Chinese populations. In the present study, 30.5%... Tipo: Info:eu-repo/semantics/article Palavras-chave: Prostate cancer; Polymorphisms; AR; SRD5A2; CYP17. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200009 Effect of Helicobacter pylori infection and acid blockade by lansoprazole on clarithromycin bioavailability BJMBR Ortiz,R.A.M.; Calafatti,S.A.; Moraes,L.A.; Deguer,M.; Ecclissato,C.C.; Marchioretto,M.A.M.; Ribeiro,M.L.; Bernasconi,G.; Pedrazzoli Jr,J.. The effect of proton pump inhibitors and Helicobacter pylori infection on the bioavailability of antibiotics is poorly understood. We determined the effects of 5-day oral administration of 60 mg lansoprazole on the bioavailability of clarithromycin in individuals with and without H. pylori infection. Thirteen H. pylori-infected and 10 non-infected healthy volunteers were enrolled in a study with an open-randomized two-period crossover design and a 21-day washout period between phases. Plasma concentrations of clarithromycin in subjects with and without lansoprazole pre-treatment were measured by liquid chromatography coupled to a tandem mass spectrometer. Clarithromycin Cmax and AUC0-10 h were significantly reduced after lansoprazole administration. In... Tipo: Info:eu-repo/semantics/article Palavras-chave: Clarithromycin; Helicobacter pylori; Lansoprazole; Peptic ulcer; Pharmacokinetics. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300014 Plasma hydroxy-metronidazole/ metronidazole ratio in hepatitis C virus-induced liver disease BJMBR Marchioretto,M.A.M.; Ecclissato,C.; Silva,C.M.F. da; Cassiano,N.M.; Calafatti,S.A.; Mendonça,S.; Ribeiro,M.L.; Bernasconi,G.C.R.; Degger,M.F.; Piovesan,H.; Pedrazzoli Jr.,J.. It has been suggested that the measurement of metronidazole clearance is a sensitive method for evaluating liver function. The aim of this study was to evaluate the usefulness of plasma hydroxy-metronidazole/metronidazole ratios as indicators of dynamic liver function to detect changes resulting from the various forms of chronic hepatitis C virus (HCV) infection. A total of 139 individuals were studied: 14 healthy volunteers, 22 healthy, asymptomatic, consecutive anti-HCV-positive HCV-RNA negative subjects, 81 patients with chronic hepatitis C (49 with moderate/severe chronic hepatitis and 34 with mild hepatitis), and 20 patients with cirrhosis of the liver. HCV status was determined by the polymerase chain reaction. Plasma concentrations of metronidazole... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metronidazole; Liver function; Hepatitis C; Cytochrome P450. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000300015 Rarity of DNA sequence alterations in the promoter region of the human androgen receptor gene BJMBR Cabral,D.F.; Santos,A.; Ribeiro,M.L.; Mesquita,J.C.; Carvalho-Salles,A.B.; Hackel,C.. The human androgen receptor (AR) gene promoter lies in a GC-rich region containing two principal sites of transcription initiation and a putative Sp1 protein-binding site, without typical "TATA" and "CAAT" boxes. It has been suggested that mutations within the 5'untranslated region (5'UTR) may contribute to the development of prostate cancer by changing the rates of gene transcription and/or translation. In order to investigate this question, the aim of the present study was to search for the presence of mutations or polymorphisms at the AR-5'UTR in 92 prostate cancer patients, where histological diagnosis of adenocarcinoma was established in specimens obtained from transurethral resection or after prostatectomy. The AR-5'UTR was amplified by PCR from... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human androgen receptor gene; Promoter region; Prostate cancer; 5'Untranslated region; DNA sequence alterations. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200004 Relationship of IL-1 and TNF-α polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population BJMBR Santos,J.C.; Ladeira,M.S.P.; Pedrazzoli Jr,J.; Ribeiro,M.L.. It is well known that the risk of development of gastric cancer (GC) in Helicobacter pylori-infected patients depends on several factors. Thus, the aim of this study was to investigate the effect of proinflammatory cytokine gene polymorphisms for IL-1β, IL-1RN and TNF-α on the development of GC in a Brazilian population. A total of 202 biopsies obtained from Brazilian patients with chronic gastritis and GC were included in the study. Infection with H. pylori cagA+ was determined by the polymerase chain reaction (PCR) as previously described. IL-1β, IL-1RN and TNF-α polymorphism genotyping was performed by restriction fragment length polymorphism PCR. Associations between gene polymorphisms, clinical diseases and virulence markers were evaluated using... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic gastritis; Gastric cancer; Polymorphisms; Helicobacter pylori; Interleukins; IL-1β; IL-1RN; TNF-α. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900004 Registros recuperados: 5 Primeira ... 1 ... Última

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